Lung Cytology & FISH — ANSWERS

 Here you find all solutions of the lung cytology quiz.

Correct answers are checked and yellow. For each diagnostic category the percentage of experts who voted for this answer is indicated.

Control cases are green (control cases are regarded to allow a clear-cut diagnosis).


Case 1

Bronchoalveolar lavage. Suspect of aspergilloma, 83 f.
Final diagnosis: Lung fibrosis.

(Click on the small thumbnail images to see the full view! Close the image window after viewing the image!)

What is your diagnosis for case 1
 1 benign — 20.4%
 2 atypical, unspecified — 9.5%
 3 atypical, favor benign — 38.7%
 4 atypical, favor malignant — 16.1%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 15.3%

Case 2

Bronchoalveolar lavage. Right lower lobe infiltrate, 24 f.
Final diagnosis: Pneumonia.

What is your diagnosis for case 2
 1 benign — 27.7%
 2 atypical, unspecified — 12.4%
 3 atypical, favor benign — 36.5%
 4 atypical, favor malignant — 13.9%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 9.5%

Case 3

Bronchial secretion. Suspect of lung cancer, 65 f.
Final diagnosis: Small cell lung cancer.

What is your diagnosis for case 3
 1 benign — 7.3%
 2 atypical, unspecified — 2.9%
 3 atypical, favor benign — 3.6%
 4 atypical, favor malignant — 13.9%
 5 carcinoma small cell — 70.1%
 6 carcinoma non small cell — 2.2%

Case 4

FNA. Suspect of lung cancer, 77 w.
Final diagnosis: Adenocarcinoma.

What is your diagnosis for case 4
 1 benign — 2.9%
 2 atypical, unspecified — 2.9%
 3 atypical, favor benign — 3.6%
 4 atypical, favor malignant — 9.5%
 5 carcinoma small cell — 1.5%
 6 carcinoma non small cell — 79.6%

Case 5

Bronchoalveolar lavage. Metastasizing adenocarcinoma of the lung, 65 m.
Final diagnosis: Adenocarcinoma.

What is your diagnosis for case 5
 1 benign — 0.7%
 2 atypical, unspecified — 1.5%
 3 atypical, favor benign — 5.8%
 4 atypical, favor malignant — 16.8%
 5 carcinoma small cell — 0.7%
 6 carcinoma non small cell — 74.5%

Case 6

FNA. Suspect of lung cancer, 68 f.
Final diagnosis: Adenocarcinoma.

What is your diagnosis for case 6
 1 benign — 10.2%
 2 atypical, unspecified — 8.0%
 3 atypical, favor benign — 14.6%
 4 atypical, favor malignant — 27.7%
 5 carcinoma small cell — 29.9%
 6 carcinoma non small cell — 9.5%

Case 7

FNA. Solitary pulmonary nodule. Absence of change in size. 58 m.
Final diagnosis: Hamartoma.

What is your diagnosis for case 7
 1 benign — 8.8%
 2 atypical, unspecified — 22.6%
 3 atypical, favor benign —29.2%
 4 atypical, favor malignant —24.1%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 15.3%

Case 8

Sputum. 79 w.
Final Diagnosis: Adenocarcinoma.

What is your diagnosis for case 8
 1 benign — 13.1%
 2 atypical, unspecified — 9.5%
 3 atypical, favor benign — 11.7%
 4 atypical, favor malignant — 19.7%
 5 carcinoma small cell — 2.2%
 6 carcinoma non small cell — 43.8%

Case 9

Sputum. Hemoptysis, 68 m.
Final diagnosis: Congestive heart failure. No tumor. No pulmonary embolism.
Hemoptysis disappeared after successful therapy of congestive heart failure.

What is your diagnosis for case 9
 1 benign — 19.7%
 2 atypical, unspecified — 11.7%
 3 atypical, favor benign — 22.6%
 4 atypical, favor malignant — 21.2%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 24.8%

Case 10

Bronchial secretion. Multiple pulmonary nodules, 64w.
Final diagnosis: Uneventful course. No malignancy.

What is your diagnosis for case 10
 1 benign — 86.9%
 2 atypical, unspecified — 2.2%
 3 atypical, favor benign — 8.8%
 4 atypical, favor malignant — 1.5%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 0.7%

Case 11

Bronchoalveolar lavage. Non small cell lung cancer after neoadjuvant chemotherapy, 40 m.
Final diagnosis: Non small cell lung cancer.

What is your diagnosis for case 11
 1 benign — 2.9%
 2 atypical, unspecified — 8.0%
 3 atypical, favor benign — 13.1%
 4 atypical, favor malignant — 21.9%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 54.0%

Case 12

Bronchial brushing cytology. Suspect of lung cancer, 75 w.
Final diagnosis: Adenocarcinoma.

What is your diagnosis for case 12
 1 benign — 0.0%
 2 atypical, unspecified — 1.5%
 3 atypical, favor benign — 0.7%
 4 atypical, favor malignant — 15.3%
 5 carcinoma small cell — 8.8%
 6 carcinoma non small cell — 73.7%

Case 13

FNA. Suspect of lung cancer, 40 m.
Final diagnosis: Non small cell lung cancer.

What is your diagnosis for case 13
 1 benign — 0.0%
 2 atypical, unspecified — 2.2%
 3 atypical, favor benign — 3.6%
 4 atypical, favor malignant — 23.4%
 5 carcinoma small cell — 2.2%
 6 carcinoma non small cell — 68.6%

Case 14

FNA lymph node. Suspect of lung cancer, 50 w.
Final diagnosis: Uneventful course. No malignancy.

What is your diagnosis for case 14
 1 benign — 62.8%
 2 atypical, unspecified — 5.1%
 3 atypical, favor benign — 13.1%
 4 atypical, favor malignant — 8.0%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 10.9%

Case 15

Bronchial secretion. Pulmonary infiltrate, 88 m.
Final diagnosis: Uneventful clinical course. No malignancy.

What is your diagnosis for case 15
 1 benign — 43.1%
 2 atypical, unspecified — 8.0%
 3 atypical, favor benign — 27.7%
 4 atypical, favor malignant — 10.9%
 5 carcinoma small cell — 9.5%
 6 carcinoma non small cell — 0.7%

Case 16

Bronchial secretion. solitary pulmonary nodule, 60 m.
Final diagnosis: Tuberculosis.

What is your diagnosis for case 16
 1 benign — 11.7%
 2 atypical, unspecified — 9.5%
 3 atypical, favor benign — 22.6%
 4 atypical, favor malignant — 24.8%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 31.4%

Case 17

Bronchial secretion. Tumor of the left lower lobe, 71 m.
Final diagnosis: Squamous cell carcinoma.

What is your diagnosis for case 17
 1 benign — 5.8%
 2 atypical, unspecified — 9.5%
 3 atypical, favor benign — 11.7%
 4 atypical, favor malignant — 29.2%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 43.8%

Case 18

Bronchial secretion. Solitary pulmonary nodule right upper lobe, 62m.
Final diagnosis: Non small cell lung cancer.

What is your diagnosis for case 18
 1 benign — 0.0%
 2 atypical, unspecified — 0.7%
 3 atypical, favor benign — 0.7%
 4 atypical, favor malignant — 18.2%
 5 carcinoma small cell — 7.3%
 6 carcinoma non small cell — 73.0%

Case 19

Bronchial secretion. Suspect of lung cancer, 69 w.
Final diagnosis: Non small cell lung cancer.

What is your diagnosis for case 19
 1 benign — 11.7%
 2 atypical, unspecified — 26.3%
 3 atypical, favor benign — 23.4%
 4 atypical, favor malignant — 20.4%
 5 carcinoma small cell — 2.2%
 6 carcinoma non small cell — 16.1%

Case 20

Bronchial secretion. Lung tumor, 73 m.
Final diagnosis: Adenocarcinoma.

What is your diagnosis for case 20
 1 benign — 10.2%
 2 atypical, unspecified — 15.3%
 3 atypical, favor benign — 17.5%
 4 atypical, favor malignant — 30.7%
 5 carcinoma small cell — 3.6%
 6 carcinoma non small cell — 22.6%

Case 21

Bronchial secretion. Suspect of recurrent lung cancer, 61 m.
Final diagnosis: Squamous cell carcinoma.

What is your diagnosis for case 21
 1 benign — 10.9%
 2 atypical, unspecified — 10.2%
 3 atypical, favor benign — 20.4%
 4 atypical, favor malignant — 28.5%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 29.9%

Case 22

Bronchial secretion. Suspect of lung cancer, 76 m.
Final diagnosis: Squamous cell carcinoma.

What is your diagnosis for case 22
 1 benign — 10.2%
 2 atypical, unspecified — 20.4%
 3 atypical, favor benign — 19.0%
 4 atypical, favor malignant — 31.4%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 19.0%

Case 23

Bronchial brushing cytology. Suspect of lung cancer, 83 m.
Final diagnosis: Small cell lung cancer.

What is your diagnosis for case 23
 1 benign — 10.2%
 2 atypical, unspecified — 14.6%
 3 atypical, favor benign — 11.7%
 4 atypical, favor malignant — 27.0%
 5 carcinoma small cell — 28.5%
 6 carcinoma non small cell — 8.0%

Case 24

Bronchoalveolar lavage. Hemoptysis. Malignant cells? 40 m.
Final diagnosis: Capillaritis and alveolar hemorrhage suspect for vasculitis.

What is your diagnosis for case 24
 1 benign — 3.7%
 2 atypical, unspecified — 7.3%
 3 atypical, favor benign — 8.0%
 4 atypical, favor malignant — 16.8%
 5 carcinoma small cell — 1.5%
 6 carcinoma non small cell — 62.8%

Case 25

Bronchial secretion. Lung abscess or tumor, 68 m.
Final diagnosis: Adenocarcinoma.

What is your diagnosis for case 25
 1 benign — 11.7%
 2 atypical, unspecified — 14.6%
 3 atypical, favor benign — 24.1%
 4 atypical, favor malignant — 16.8%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 32.9%

Case 26

FNA. Suspect of lung cancer, 62 w.
Final diagnosis: Small cell lung cancer.

What is your diagnosis for case 26
 1 benign — 3.6%
 2 atypical, unspecified — 5.1%
 3 atypical, favor benign — 8.0%
 4 atypical, favor malignant — 21.9%
 5 carcinoma small cell — 43.8%
 6 carcinoma non small cell — 17.5%

Case 27

Bronchial secretion. Pleural effusion, 72 m.
Final diagnosis: Adenocarcinoma.

What is your diagnosis for case 27
 1 benign — 19.0%
 2 atypical, unspecified — 19.7%
 3 atypical, favor benign — 21.9%
 4 atypical, favor malignant — 15.3%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 24.1%

Case 28

Bronchial brushing cytology. Tumor of the right lung, 73 w.
Final diagnosis: Adenocarcinoma.

What is your diagnosis for case 28
 1 benign — 5.1%
 2 atypical, unspecified — 16.1%
 3 atypical, favor benign — 15.3%
 4 atypical, favor malignant — 37.2%
 5 carcinoma small cell — 0.0%
 6 carcinoma non small cell — 26.3%

Case 29

Bronchial secretion. Tumor of the right lower lobe, 75 w.
Final diagnosis: Breast cancer metastasis.

What is your diagnosis for case 29
 1 benign — 40.9%
 2 atypical, unspecified — 2.2%
 3 atypical, favor benign — 11.7%
 4 atypical, favor malignant — 16.1%
 5 carcinoma small cell — 8.8%
 6 carcinoma non small cell — 20.4%

Case 30

Bronchial brushing cytology. Reticulonodular infiltrate, 65 m.
Final diagnosis: Infiltrate resolved. Uneventful clicinal course.

What is your diagnosis for case 30
 1 benign — 31.4%
 2 atypical, unspecified — 14.6%
 3 atypical, favor benign — 21.9%
 4 atypical, favor malignant — 16.8%
 5 carcinoma small cell — 9.5%
 6 carcinoma non small cell — 5.8%

Thank you very much for participating!



Pathorama© Institut für Pathologie Basel / Dr. med. Katharina Glatz-Krieger
    Universitätsrechenzentrum / Dr. Dieter Glatz